, with a particular focus on medication adherence (MA) in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The study, which delves into the complexities of these rare and life-threatening conditions, underscores the significance of maintaining high medication adherence to improve patient outcomes.){kind=link}
A recent systematic review has provided critical insights into the management of pulmonary hypertension (PH), with a particular focus on medication adherence (MA) in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The study, which delves into the complexities of these rare and life-threatening conditions, underscores the significance of maintaining high medication adherence to improve patient outcomes.
PH encompasses a wide range of pathophysiological disorders, with PAH and CTEPH being notably severe due to their potential to cause right ventricular failure and death if left untreated. Over the past two decades, advancements in pharmaceutical therapies targeting specific pathways, including prostacyclin, endothelin, nitric oxide, and guanylate cyclase, have significantly improved survival and quality of life for patients. Current guidelines recommend a combination of these treatments tailored to the patient’s risk status at diagnosis and during follow-up.
The review highlights the crucial role of medication adherence in the effective management of PAH and CTEPH. High adherence to prescribed therapies is associated with better health outcomes, while poor adherence can lead to suboptimal clinical results. The study emphasizes that regular monitoring of medication adherence by a multidisciplinary team is essential to promptly address any issues or changes in treatment.
Additionally, the review explores various factors that influence medication adherence, including patient-related factors, the nature of the disease, treatment regimens, patient-healthcare team relationships, and socioeconomic status. The findings suggest that a comprehensive approach, integrating both specific and nonspecific therapies along with lifestyle and dietary guidelines, is vital for optimal management.
This study aims to enhance the understanding of medication adherence in PH patients, providing insights into assessment methodologies, identifying factors associated with adherence levels, and exploring the clinical outcomes linked to adherence. The findings are expected to guide healthcare providers in developing strategies to improve adherence and, consequently, patient outcomes in PAH and CTEPH management.